Evidence from several studies has indicated that low serotonin levels may play a role in the development of fibromyalgia.   

It is believed that serotonin abnormalities could be responsible for depression and insomnia—symptoms that many fibromyalgia patients suffer from.  Because 5-HTP could raise low serotonin levels, it may be helpful in alleviating such symptoms. 

Although no one knows exactly why 5-HTP effectively improves fibromyalgia symptoms, researchers believe that low levels of the neurotransmitter serotonin may be involved in symptoms associated with fibromyalgia, as mentioned above.  Serotonin is believed to mediate slow-wave (deep) sleep, as well as influence how pain is perceived by the body and mind. 

Leading sleep and fibromyalgia experts H. Moldofsky and J.J. Warsh theorize that primary fibromyalgia may result from a deficiency of circulating tryptophan, an amino acid.  This lack of tryptophan in turn restricts serotonin and interferes with what is known as deep sleep. The researchers also reported that the higher the concentration of unbound tryptophan in the plasma of FMS patients, the more profound their symptoms. (1)

Additionally, 5-HTP is the intermediate between tryptophan and serotonin and it is readily absorbed and crosses the blood-brain barrier.  It is also promoted for depression. (2)

Even though the cause of depression varies widely from one person to the next, most people with depression have low serotonin levels. Whether low levels of serotonin cause depression or depression causes serotonin levels to fall is not yet clear but what is certain is that by raising serotonin levels depression can often be alleviated.

A 90-day study of the effects of 5-HTP on 50 fibromyalgia patients published in The Journal of International Medical Research; 1992; 20:182 – 189 concluded that a “good” or “fair” clinical improvement occurred in 50 per cent of the patients. These patients ranged in age from 18 to 65. When clinical variables such as tender point soreness, anxiety, pain intensity, quality of sleep and fatigue were compared with baseline results, researchers concluded that all symptoms had been  improved after 90 days of taking 100 milligrams of 5-HTP three times daily.

Low levels of serotonin in the brain can contribute to the development of depression.  Some studies indicate that 5-HTP may be as effective as certain antidepressant drugs in treating individuals with mild to moderate depression. Such individuals have shown improvements in mood, anxiety, insomnia, and physical symptoms.

1.  H. Moldofsky and J.J. Warsh; Pain; 1978; 5:65 71;  
2.  Birdsall, Altern Med Rev 8/98;3:271.

Ketsumeisei is a proprietary Chinese herbal formula that affects the entire body.  It has been found to help maintain stabilized blood sugar and improve insulin resistance by helping to lower free fatty acid in the body, according to clinical studies.

Insulin resistance and free fatty acid have been identified as being contributing factors to the onset of diabetes. Our rapidly changing modern lifestyle has also resulted in a sharp increase in the incidence of Type II diabetes mellitus, which is now a major problem for society.

What is Ketsumeisei?

Ketsumeisei contains Sicklepod Senna, Chinese Wild Yam, Safflower, Astragalus Root, Cape Jasmine Fruit, Kudzu Vine Root, Chinese Licorice, Chinese Ginseng.  Clinical studies have shown that this combination of herbs can be taken to help with metabolic and microcirculatory disturbances like those associated with Type II diabetes mellitus and insulin resistance.

Ketsumeisei is indicated for the maintenance of normalized blood sugar levels and insulin resistance disorders, such as:

• Obesity
• Hyperlipidemia
• Hyperinsulinemia
• Hypertension
• Arteriosclerosis
• Arteriosclerotic diseases

Diabetes mellitus has become increasingly prevalent, so much so that it is, in fact, currently referred to as a “national affliction.”  Type II diabetes, which accounts for about 95% of diabetes mellitus, results from insufficient insulin secretion and insulin resistance (in which insulin cannot be used effectively). 

Additionally, genetic factors are involved in its etiology, but stress, overeating, lack of exercise, and other modern lifestyle habits also play a large role.  These predisposing factors promote the formation of the “diabetic constitution,” which is characterized by metabolic and circulatory disorders.

Results

In one study, 60% of diabetics taking Ketsumeisei experienced decreased glucose within 2 months. Nearly 100% of diabetics experienced improvement of subjective symptoms during the same time period.

Treatments for diabetics has always included lowering and controlling the patient’s blood sugar levels, yet this approach often fails to stop further complications and may cause serious side effects, especially, when the patient is taking several drugs. Ketsumeisei offers a way to improve symptoms to help prevent more damage.

Clinical studies have shown that in Type II diabetic patients, Ketsumeisei can clearly:

• Help improve metabolism
• Help lower blood pressure
• Help increase ATP (energy of the cells)
• Help decrease or maintain glucose levels
• Help decrease free fatty acid, which may contribute to insulin resistance

Read more about Ketsumeisei here

Over the past 2 decades, there has been a dramatic increase in the scientific study and public interest in omega-3 fatty acids and the positive impact they may have on our health. These special omega-3 fatty acids have been shown to possess anti-inflammatory, anti-arrhythmic, and anti-thrombotic properties.Omega 3’s can be helpful for conditions such as arthritis by reducing stiffness, inflammation, and joint pain.  They can also help support a healthy cardiovascular system by thinning the blood, dilating blood vessels, and supporting healthy blood pressure.  

Read Our Article

Omega 3 and Omega 6 Fatty Acids: Balancing the Good Fats

Essential Fatty Acid Basics

Omega 3 fatty acids are considered “essential” because they cannot be manufactured within the body.  Therefore, they must be obtained from food sources, such as fish, plant, and nut oils.  We need them for our bodies to work normally. Because essential fatty acids (ALA, DHA, EPA) are not made in the body or are inefficiently converted from ALA to EPA and DHA, we need to get them from food.

Symptoms of omega 3 fatty acid deficiency includes:

• Extreme tiredness
• Poor memory
• Dry skin
• Heart problems
• Mood swings
• Depression
• Poor circulation

Omega-3s have a number of reported health benefits. They can help reduce inflammation throughout the body — in the blood vessels, the joints, and elsewhere. Omega-3 supplements (EPA/DHA) also seem to thin the blood and aid cell function.

There are several types of omega-3 fatty acids. However, the two most crucial ones EPA and DHA — are primarily found in certain fish. Plants like flax contain ALA, an omega-3 fatty acid that is partially converted into DHA and EPA in the body.  Experts say that DHA and EPA — from fish and fish oil — have better established health benefits than ALA. DHA and EPA are found togetheronly in fatty fish and algae; while flaxseed and plant sources of omega-3s provide ALA — a precursor to EPA and DHA, and a source of energy.

Additionally, EPA and DHA are the building blocks for hormones that control immune function, blood clotting, and cell growth.  Furthermore, extensive research has shown that omega 3 fatty acids help reduce risk factors associated with chronic diseases, such as arthritis and heart disease.

Source:  WebMD

Omega 3’s and Cardiovascular Health

Evidence is steadily accumulating indicating that omega 3 fatty acids found in fish help decrease the risk of coronary heart disease.  In fact, the Nurses’ health study and the Physician’s health study are two large, long-term observational studies that have been published regarding dietary intake omega-3-fatty acids and the risk of heart disease and sudden cardiac death:

Nurses’ Health Study -  This study began in 1976.   More than 80,000 female nurses completed life style and diet questionnaires.  Then, they were monitored for 16 years for the development of coronary heart disease. Omega-3 fatty acid consumption was calculated from the questionnaires. The results of the study showed that compared to women who rarely ate fish (less than one fish meal per month), women who ate fish once a week had a 29% lower risk of developing coronary heart disease. Those who ate fish five times a week had a 34% reduction in the risk of coronary heart disease and a 45% reduction in the risk of death from heart disease (usually sudden cardiac death). 1

Physicians Health Study – The Physician’s health study began in 1982 when more than 20,000 healthy male physicians were followed for 11 years. Life style, coronary risk factors and diet data were collected at entry, and life style and diet data were collected via questionnaires at 12 months and 18 months. The results of the study showed that men who consumed one or more fish meals per week had a 50% lower risk of developing sudden cardiac death than men who rarely ate fish (less than one fish meal per month). 2

According to WebMD, “Omega-3 fatty acids appear to lower the overall risk of death from heart disease.  Fish oil may reduce arrhythmias, and people who take omega-3 supplements after a heart attack cut their risk of having another heart attack.  Eating fish once or twice a week seems to significantly lower the risk of stroke.”

Omega 3’s and Rheumatoid Arthritis

Rheumatoid arthritis is a chronic autoimmunedisease, characterized by inflammation of the synovial lining of the joints. Rheumatoid arthritis may also affect other organs of the body, including the skin, eyes, lungs and heart.

Omega 3’s have been shown to help reduce inflammation in the body, thereby, offering relief to those who suffer from inflammatory joint conditions. 

The majority of clinical studies that have investigated the use of omega-3 fatty acid supplements for inflammatory joint conditions have focused primarily on rheumatoid arthritis. These studies have concluded that omega-3 fatty acid supplements help reduce tenderness in joints, decrease morning stiffness, and allow for a reduction in the amount of medication needed for people with rheumatoid arthritis.  Additionally, laboratory studies suggest that diets rich in omega-3 fatty acids may benefit people with other inflammatory disorders, such as osteoarthritis. 3, 4

The Physician’s Desk Reference for Nutritional Supplements suggests that a “daily ingestion of at least 3 grams of EPA and DHA mixtures of a period of 12 weeks or longer has been found to reduce the number of tender joints and amount of morning stiffness in subjects with rheumatoid arthritis.  Those with rheumatoid arthritis consuming these supplements have been report to lower or discontinue use of non-steroidal anti-inflammatory drugs or disease-modifying anti-rheumatic drugs.”

Further Reading

Diet, atherosclerosis, and fish oil.

N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients.

Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction.

Omega-3 fatty acids in rheumatoid arthritis: an overview.

A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.

Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis.

References

1.  JAMA vol 287. No.14, p 1815. “Fish and omega-3-fatty acid intake and risk of coronary heart disease in women”.

2.  JAMA 1998, vol 279, p23. The title of the article is “Fish consumption and risk of sudden cardiac death”.

3.  MacLean CH, Mojica WA, Morton SC, et al. Effects of omega-3 fatty acids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosis. Evid Rep Technol Assess (Summ). 2004(89):1-4. 

4. Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007;129(1-2):210-223.